HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Trifluoromethoxy)benzaldehyde → (7bR,11aS)-N-[2-(trifluoromethoxy)benzyl]-1,2,7b,8,9,10,11,11a-octahydro-4H-pyrido[4,3-b][1,4]thiazepino[6,5,4-hi]indol-6-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Trifluoromethoxy)benzaldehyde | HCID 2777192 | — |
| Reactant | tert-butyl (7bR,11aS)-6-amino-1,2,7b,10,11,11a-hexahydro-4H-pyrido[4,3-b][1,4]thiazepino[6,5,4-hi]indole-9(8H) carboxylate | HCID 86586437 | — |
| Product | (7bR,11aS)-N-[2-(trifluoromethoxy)benzyl]-1,2,7b,8,9,10,11,11a-octahydro-4H-pyrido[4,3-b][1,4]thiazepino[6,5,4-hi]indol-6-amine | HCID 60071870 | — |
Reaction Steps
Using 2-(trifluoromethoxy)benzaldehyde and following the procedures described in EXAMPLE 126, tert-butyl (7bR,11aS)-6-amino-1,2,7b,10,11,11a-hexahydro-4H-pyrido[4,3-b][1,4]thiazepino[6,5,4-hi]indole-9(8H)-carboxylate from EXAMPLE 33, Part B was converted into the title compound of EXAMPLE 165. LRMS (ES)+: 436.4 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06849619B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-7742cf67d29c4a4abad20459971de61d |
| Source note | uspto-grants-2005_02 |