4-(Trifluoromethoxy)phenylboronic acid → [2,6-Dimethyl-4-[4-(trifluoromethoxy)phenyl]phenyl]-[4-[2-(hydroxymethyl)pyrrolidin-1-yl]piperidin-1-yl]methanone

HRID 2329700Notes

Reaction equation

HRID 2329700 reaction equation
[Br:1][c:2]1[cH:3][c:4]([CH3:24])[c:5]([C:9](=[O:10])[N:11]2[CH2:12][CH2:13][CH:14]([N:17]3[CH:18]([CH2:22][OH:23])[CH2:19][CH2:20][CH2:21]3)[CH2:15][CH2:16]2)[c:6]([CH3:8])[cH:7]1.[F:25][C:26]([O:27][c:28]1[cH:29][cH:30][c:31]([B:34]([OH:35])[OH:36])[cH:32][cH:33]1)([F:37])[F:38]>>[c:2]1(-[c:31]2[cH:30][cH:29][c:28]([O:27][C:26]([F:25])([F:37])[F:38])[cH:33][cH:32]2)[cH:3][c:4]([CH3:24])[c:5]([C:9](=[O:10])[N:11]2[CH2:12][CH2:13][CH:14]([N:17]3[CH:18]([CH2:22][OH:23])[CH2:19][CH2:20][CH2:21]3)[CH2:15][CH2:16]2)[c:6]([CH3:8])[cH:7]1

Participants

3

Reactant 2

HCID 27343864-(Trifluoromethoxy)phenylboronic acidHCID 66901578(4-Bromo-2,6-dimethylphenyl)-[4-[2-(hydroxymethyl)pyrrolidin-1-yl]piperidin-1-yl]methanone

Product 1

HCID 66901600[2,6-Dimethyl-4-[4-(trifluoromethoxy)phenyl]phenyl]-[4-[2-(hydroxymethyl)pyrrolidin-1-yl]piperidin-1-yl]methanone

Sources & evidence

ORD record
ord-b0849b1b3d3542a5af1b55bb70142ae5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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