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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 232977Generated: October 30, 2026

Trifluoroacetic acid → 4'-[(2-Ethoxy-4-methyl-6-(1-cyclopropylmethyl-imidazol-4-yl)-benzimidazol-1-yl)-methyl]-biphenyl-2-carboxylic Acid

https://huagongshe.com/reaction/232977

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantTert.butyl 4'-[(2-ethoxy-4-methyl-6-(1-cyclopropylmethyl-imidazol-4-yl)-benzimidazol-1-yl)-methyl]-biphenyl-2-carboxylateHCID 67708521—
SolventDichloromethaneHCID 6344—
Product4'-[(2-Ethoxy-4-methyl-6-(1-cyclopropylmethyl-imidazol-4-yl)-benzimidazol-1-yl)-methyl]-biphenyl-2-carboxylic AcidHCID 19964430—

Reaction Steps

Prepared analogously to Example 88 from tert.butyl 4'-[(2-ethoxy-4-methyl-6-(1-cyclopropylmethyl-imidazol-4-yl)-benzimidazol-1-yl)-methyl]-biphenyl-2-carboxylate and trifluoroacetic acid in methylene chloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05591762
Source datasetuspto-grants-1997_01
ORD IDord-f2ebdad1edb24a05a3a4718ac909da37
Source noteuspto-grants-1997_01