HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 131724732, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 3-Bromo-2-ethoxy-6-(trifluoromethyl)pyridine | HCID 69902082 | — |
| Reactant | Tert-butyl (7br,11as)-6-amino-1,2,7b,10,11,11a-hexahydro-4h-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indole-9(8h)carboxylate | HCID 86586438 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Product | HCID 131724732 | HCID 131724732 | — |
Reaction Steps
Following the procedures described in Example 175 and using 3-bromo-2-ethoxy-6 (trifluoromethyl)pyridine and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium (II), complex with dichloromethane, as the palladium source, tert-butyl (7bR,11aS)-6-amino-1,2,7b,10,11,11a-hexahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indole-9(8H)-carboxylate from Example 56, Part B was converted into the title compound of Example 198 as a solid. ESI MS m/z 435.4 [C22H25F3N4O2+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06849619B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-a846c87d4b5941cc82ab97f260b433cb |
| Source note | uspto-grants-2005_02 |