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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 232994Generated: October 26, 2026

N-methyl-formamide methylamine → 4'-[[2-n-Propyl-4-methyl-6-(1,4,5-trimethyl-imidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic Acid

https://huagongshe.com/reaction/232994

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-methyl-formamide methylamineHCID 20318572—
Reactanttert.butyl 4'-[[2-n-propyl-4-methyl-6-(4,5-dimethyl-oxazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylateHCID 67708414—
Product4'-[[2-n-Propyl-4-methyl-6-(1,4,5-trimethyl-imidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic AcidHCID 54356497—

Reaction Steps

Prepared analogously-to Example 146 from tert.butyl 4'-[[2-n-propyl-4-methyl-6-(4,5-dimethyl-oxazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate and N-methyl-formamide/methylamine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05591762
Source datasetuspto-grants-1997_01
ORD IDord-cdfea2a1a9424b03946d0504a26fe27f
Source noteuspto-grants-1997_01