反应详情

Following the procedures described in Example 175 and using 3-bromo-2-ethoxy-5-(trifluoromethyl)pyridine and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium (II), complex with dichloromethane, as the palladium source, tert-butyl (7bR,11aS)-6-amino-1,2,7b,10,11,11a-hexahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indole-9(8H)-carboxylate from Example 56, Part B was converted into the title compound of Example 199 as a solid. ESI MS m/z 435.3 [C22H25F3N4O2+H]+.