5-Bromo-3,3-dimethyl-isoindolin-1-one → 5-{8-[4-(4-Isopropylpiperazin-1-yl)-phenylamino]-[1,2,4]triazolo[1,5-a]pyrazin-5-yl}-3,3-dimethyl-2,3-dihydroisoindol-1-one

HRID 2330176Notes

Reaction equation

HRID 2330176 reaction equation
[BH:14]([O-:15])[O-:16].[Br:17][c:18]1[cH:19][n:20][c:21]([NH:27][c:28]2[cH:29][cH:30][c:31]([N:34]3[CH2:35][CH2:36][N:37]([CH:40]([CH3:41])[CH3:42])[CH2:38][CH2:39]3)[cH:32][cH:33]2)[c:22]2[n:23]1[n:24][cH:25][n:26]2.[Br:1][c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[C:7](=[O:11])[NH:6][C:5]2([CH3:12])[CH3:13]>>[c:2]1(-[c:18]2[cH:19][n:20][c:21]([NH:27][c:28]3[cH:29][cH:30][c:31]([N:34]4[CH2:35][CH2:36][N:37]([CH:40]([CH3:41])[CH3:42])[CH2:38][CH2:39]4)[cH:32][cH:33]3)[c:22]3[n:23]2[n:24][cH:25][n:26]3)[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[C:7](=[O:11])[NH:6][C:5]2([CH3:12])[CH3:13]

Participants

4

Reactant 3

HCID 575899965-Bromo-3,3-dimethyl-isoindolin-1-oneHCID 57590046(5-Bromo[1,2,4]triazolo[1,5-a]pyrazin-8-yl)-[4-(4-isopropylpiperazin-1-yl)-phenyl]amineHCID 178514824HCID 178514824, compound

Product 1

HCID 248896265-{8-[4-(4-Isopropylpiperazin-1-yl)-phenylamino]-[1,2,4]triazolo[1,5-a]pyrazin-5-yl}-3,3-dimethyl-2,3-dihydroisoindol-1-one

Sources & evidence

ORD record
ord-031731124f2b4e30bcbeb281091b1115
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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