Pyridine → HCID 10056769, compound

Participants

Reaction Steps

A solution of oxiranylmethyl [3,5-bis [[[2-(acetyloxy)-1-[(acetyloxy)methyl]ethyl]amino]carbonyl]-2,4,6-triiodophenyl]carbamate of Example 3a (12.1 g, 12.4 mmol) in freshly distilled anhydrous pyridine (120 ml) was heated at 75° C. for 45 minutes. Pyridine was removed under diminished pressure at 45° C. and the residue was co-evaporated twice with toluene (75 ml). The solid thus obtained was dissolved in ethyl acetate (250 ml) and the solution was washed with H2O (1×100 ml). The organic layer was dried (MgSO4). It was then filtered and the solvent removed to obtain the title compound as a yellow solid (9.2 g).

Provenance & Evidence