Dimethyl Sulfoxide → Benzenamine, 4-[2-chloro-4-(trifluoromethyl)phenoxy]-2-fluoro-

HRID 2330767Notes

Reaction equation

HRID 2330767 reaction equation
[CH3:24][S:25]([CH3:26])=[O:27].[Cl:12][c:13]1[c:14]([Cl:23])[cH:15][c:16]([C:19]([F:20])([F:21])[F:22])[cH:17][cH:18]1.[Cl:29][CH2:30][Cl:31].[F:1][c:2]1[c:3]([NH2:4])[cH:5][cH:6][c:7]([OH:9])[cH:8]1.[K+:11].[OH-:10].[OH2:28]>>[F:1][c:2]1[c:3]([NH2:4])[cH:5][cH:6][c:7]([O:9][c:13]2[c:14]([Cl:23])[cH:15][c:16]([C:19]([F:20])([F:21])[F:22])[cH:17][cH:18]2)[cH:8]1

Participants

8

Reactant 7

HCID 679Dimethyl SulfoxideHCID 813Potassium CationHCID 961HydroxideHCID 962WaterHCID 6344DichloromethaneHCID 94813,4-DichlorobenzotrifluorideHCID 27359194-Amino-3-fluorophenol

Product 1

HCID 15595105Benzenamine, 4-[2-chloro-4-(trifluoromethyl)phenoxy]-2-fluoro-

Sources & evidence

ORD record
ord-907212bc58fa4e7abf7330d4d127072f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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