Methanol → 3-(hydroxymethyl)-4H-pyrimido[2,1-a]isoquinolin-4-one

HRID 2331099Notes

Reaction equation

HRID 2331099 reaction equation
[CH2:22]([Al+:23][CH2:24][CH:25]([CH3:26])[CH3:27])[CH:28]([CH3:29])[CH3:30].[CH2:41]([Cl:42])[Cl:43].[CH3:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36].[CH3:44][OH:45].[CH:37]([Cl:38])([Cl:39])[Cl:40].[H-:21].[O:1]=[c:2]1[c:3]([C:16](=[O:17])[O:18][CH2:19][CH3:20])[cH:4][n:5][c:6]2[n:7]1[cH:8][cH:9][c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]21>>[O:1]=[c:2]1[c:3]([CH2:16][OH:17])[cH:4][n:5][c:6]2[n:7]1[cH:8][cH:9][c:10]1[cH:11][cH:12][cH:13][cH:14][c:15]21

Participants

8

Reactant 7

HCID 887MethanolHCID 6212ChloroformHCID 6344DichloromethaneHCID 8058HexaneHCID 166653HydrideHCID 13851097Ethyl 4-Oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylateHCID 16686348Bis(2-methylpropyl)alumanylium

Product 1

HCID 138510983-(hydroxymethyl)-4H-pyrimido[2,1-a]isoquinolin-4-one

Sources & evidence

ORD record
ord-678d853d209f4d438b19703f77c4cd34
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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