5-Ethynylthiophene-2-sulfonamide → 5-[8-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-imidazo[1,2-b]pyridazin-3-ylethynyl]-thiophene-2-sulfonic acid amide

HRID 2331148Notes

Reaction equation

HRID 2331148 reaction equation
[C:25](#[CH:26])[c:27]1[cH:28][cH:29][c:30]([S:32](=[O:33])(=[O:34])[NH2:35])[s:31]1.[I:1][c:2]1[cH:3][n:4][c:5]2[n:6]1[n:7][c:8](-[c:15]1[cH:16][cH:17][c:18]([C:21]([F:22])([F:23])[F:24])[cH:19][cH:20]1)[cH:9][c:10]2[C:11]([F:12])([F:13])[F:14]>>[c:2]1([C:26]#[C:25][c:27]2[cH:28][cH:29][c:30]([S:32](=[O:33])(=[O:34])[NH2:35])[s:31]2)[cH:3][n:4][c:5]2[n:6]1[n:7][c:8](-[c:15]1[cH:16][cH:17][c:18]([C:21]([F:22])([F:23])[F:24])[cH:19][cH:20]1)[cH:9][c:10]2[C:11]([F:12])([F:13])[F:14]

Participants

3

Reactant 2

HCID 860437955-Ethynylthiophene-2-sulfonamideHCID 866080243-Iodo-8-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-imidazo[1,2-b]pyridazine

Product 1

HCID 167382725-[8-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-imidazo[1,2-b]pyridazin-3-ylethynyl]-thiophene-2-sulfonic acid amide

Sources & evidence

ORD record
ord-2dfb2390621e47049563bab15840c73f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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