1-(Methylsulfonyl)-4-(4-piperidinyl)piperazine → 2-(3,4-dimethyl-benzyl)-1-[4-(4-methanesulphonyl-piperazin-1-yl)-piperidin-1-yl]-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butan-1,4-dione
Reaction equation
[CH3:1][c:2]1[cH:3][c:4]([CH2:5][CH:6]([C:7](=[O:8])[OH:9])[CH2:10][C:11]([N:12]2[CH2:13][CH2:14][CH:15]([N:18]3[C:19](=[O:28])[NH:20][c:21]4[cH:22][cH:23][cH:24][cH:25][c:26]4[CH2:27]3)[CH2:16][CH2:17]2)=[O:29])[cH:30][cH:31][c:32]1[CH3:33].[CH3:34][S:35](=[O:36])(=[O:37])[N:38]1[CH2:39][CH2:40][N:41]([CH:44]2[CH2:45][CH2:46][NH:47][CH2:48][CH2:49]2)[CH2:42][CH2:43]1>>[CH3:1][c:2]1[cH:3][c:4]([CH2:5][CH:6]([C:7](=[O:8])[N:47]2[CH2:46][CH2:45][CH:44]([N:41]3[CH2:40][CH2:39][N:38]([S:35]([CH3:34])(=[O:36])=[O:37])[CH2:43][CH2:42]3)[CH2:49][CH2:48]2)[CH2:10][C:11]([N:12]2[CH2:13][CH2:14][CH:15]([N:18]3[C:19](=[O:28])[NH:20][c:21]4[cH:22][cH:23][cH:24][cH:25][c:26]4[CH2:27]3)[CH2:16][CH2:17]2)=[O:29])[cH:30][cH:31][c:32]1[CH3:33]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-d382c959dde84a2cabd8370f36f2bfdf
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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