4-(Chloromethyl)-1,3-thiazole → N-[1-[4-[3-chloro-4-(1,3-thiazol-4-ylmethoxy)anilino]quinazolin-5-yl]oxypropan-2-yl]-2-hydroxy-N-methylacetamide

HRID 2332459Notes

Reaction equation

HRID 2332459 reaction equation
[Cl:1][CH2:2][c:3]1[n:4][cH:5][s:6][cH:7]1.[Cl:8][c:9]1[cH:10][c:11]([NH:16][c:17]2[n:18][cH:19][n:20][c:21]3[cH:22][cH:23][cH:24][c:25]([O:27][CH2:28][CH:29]([CH3:30])[N:31]([C:32]([CH2:33][OH:34])=[O:35])[CH3:36])[c:26]23)[cH:12][cH:13][c:14]1[OH:15]>>[CH2:2]([c:3]1[n:4][cH:5][s:6][cH:7]1)[O:15][c:14]1[c:9]([Cl:8])[cH:10][c:11]([NH:16][c:17]2[n:18][cH:19][n:20][c:21]3[cH:22][cH:23][cH:24][c:25]([O:27][CH2:28][CH:29]([CH3:30])[N:31]([C:32]([CH2:33][OH:34])=[O:35])[CH3:36])[c:26]23)[cH:12][cH:13]1

Participants

3

Reactant 2

HCID 27632904-(Chloromethyl)-1,3-thiazoleHCID 178458266HCID 178458266, compound

Product 1

HCID 11341262N-[1-[4-[3-chloro-4-(1,3-thiazol-4-ylmethoxy)anilino]quinazolin-5-yl]oxypropan-2-yl]-2-hydroxy-N-methylacetamide

Sources & evidence

ORD record
ord-8b2d9813f1fb4cc2925c67d98587de48
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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