2-Bromo-3-[2-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-5-pyridyl]propionitrile → 3-[2-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethoxy]-5-pyridyl]propionitrile

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A mixture of 2-bromo-3-[2-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-5-pyridyl]propionitrile (2.0 g), palladium-carbon (5%, 0.2 g) and dioxane (30 ml) was subjected to catalytic reduction under 1 atmospheric pressure at room temperature. The catalyst was filtered off, then the filtrate was concentrated under reduced pressure. The concentrate was subjected to a silica gel column chromatography. From the fractions eluted with ethyl acetate--hexane (2:3, v/v), was obtained 3-[2-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-5-pyridyl]propionitrile (1.3 g, 78%), which was recrystallized from ethyl acetate--hexane to give colorless crystals, m.p.105°-106° C.

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