Dimethylformamide → HCID 10936494, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]propyl bromide (1.5 g), powdered potassium cyanide (1.52 g) and N,N-dimethylformamide (30 ml) was stirred for 3 hours at 80° C. The reaction mixture was poured into water, which was subjected to extraction with ethyl acetate. The ethyl acetate layer was washed with water and dried (MgSO4), which was then concentrated to give 4-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]butyronitrile (1.2 g, 92%). Recrystallization of the product from ethyl acetate--hexane gave colorless needles, m.p.73°-74° C.

Provenance & Evidence