Trimethyl phosphonoacetate → HCID 54514911, compound

HRID 233303Notes

Reaction equation

[CH3:1][C:2]1[S:6][C:5]([CH2:7][O:8][C:9]2[CH:16]=[CH:15][C:12]([CH:13]=O)=[CH:11][CH:10]=2)=[N:4][C:3]=1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[CH3:23][O:24][C:25]([CH2:27]P(OC)(OC)=O)=[O:26]>>[CH3:1][C:2]1[S:6][C:5]([CH2:7][O:8][C:9]2[CH:16]=[CH:15][C:12]([CH:13]=[CH:27][C:25]([O:24][CH3:23])=[O:26])=[CH:11][CH:10]=2)=[N:4][C:3]=1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

Reactant 2

HCID 80029Trimethyl phosphonoacetate

HCID 23361359HCID 23361359, compound

Product 1

HCID 54514911HCID 54514911, compound

Procedure

According to the method described for Reference Example 22, 4-(5-methyl-4-phenyl-2-thiazolylmethoxy)benzaldehyde was allowed to react with trimethyl phosphonoacetate to give methyl 4-(5-methyl-4-phenyl-2-thiazolylmethoxy)cinnamate. Recrystallization from ethyl acetate--hexane gave colorless prisms, m.p.142°-143° C.

Sources & evidence

ORD record: ord-f146ea2a630f4f36bbb9722c9bb7ef48
Source dataset: uspto-grants-1997_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05591862

Reaction notes

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