Trimethyl phosphonoacetate → HCID 53694264, compound

HRID 233308Notes

Reaction equation

[CH3:1][C:2]1[O:6][C:5]([CH2:7][O:8][C:9]2[CH:16]=[CH:15][C:12]([CH:13]=O)=[CH:11][CH:10]=2)=[N:4][C:3]=1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[CH3:23][O:24][C:25]([CH2:27]P(OC)(OC)=O)=[O:26]>>[CH3:1][C:2]1[O:6][C:5]([CH2:7][O:8][C:9]2[CH:16]=[CH:15][C:12]([CH:13]=[CH:27][C:25]([O:24][CH3:23])=[O:26])=[CH:11][CH:10]=2)=[N:4][C:3]=1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

Reactant 2

HCID 80029Trimethyl phosphonoacetate

HCID 11077219HCID 11077219, compound

Product 1

HCID 53694264HCID 53694264, compound

Procedure

According to the method described for Reference Example 22, 4-(5-methyl-4-phenyl-2-oxazolylmethoxy)benzaldehyde was allowed to react with trimethyl phosphonoacetate to give methyl 4-(5-methyl-4-phenyl-2-oxazolylmethoxy)cinnamate. Recrystallization from ethyl acetate--isopropyl ether gave colorless prisms, m.p.109°-110° C.

Sources & evidence

ORD record: ord-5f0778636e884fcf9dddb4d99a16ae01
Source dataset: uspto-grants-1997_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05591862

Reaction notes

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