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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 233313Generated: October 29, 2026

Trimethyl phosphonoacetate → Methyl 4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]cinnamate

https://huagongshe.com/reaction/233313

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrimethyl phosphonoacetateHCID 80029—
Reactant4-[5-Methyl-2-(2-naphthyl)-4-oxazolylmethoxy]benzaldehydeHCID 18546159—
ProductMethyl 4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]cinnamateHCID 54323026—

Reaction Steps

According to the method described for Reference Example 22, 4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]benzaldehyde was allowed to react with trimethyl phosphonoacetate to give methyl 4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]cinnamate. Recrystallization from chloroform-ether gave colorless prisms, m.p.185°-186° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05591862
Source datasetuspto-grants-1997_01
ORD IDord-152d5eb25740496a8d77922a131c7938
Source noteuspto-grants-1997_01