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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 233314Generated: October 31, 2026

Diisobutylaluminumhydride → (E)-3-[4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]phenyl]-2-propen-1-ol

https://huagongshe.com/reaction/233314

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiisobutylaluminumhydrideHCID 21225700—
ReactantMethyl 4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]cinnamateHCID 54323026—
Product(E)-3-[4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]phenyl]-2-propen-1-olHCID 23361385—

Reaction Steps

According to the method described for Reference Example 23, methyl 4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]cinnamate was subjected to reduction with diisobutylaluminum hydride to give (E)-3-[4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]phenyl]-2-propen-1-ol. Recrystallization from chloroform-ether gave colorless prisms, m.p.159°-160° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05591862
Source datasetuspto-grants-1997_01
ORD IDord-0de606c67d2a4d1cb8e810b1f0acfd0c
Source noteuspto-grants-1997_01