HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Chloromethyl)-5-methyl-2-(naphthalen-2-yl)-1,3-oxazole → 4-[4-[5-Methyl-2-(2-naphthyl)-4-oxazolylmethoxy]phenyl]butyronitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Chloromethyl)-5-methyl-2-(naphthalen-2-yl)-1,3-oxazole | HCID 12158073 | — |
| Reactant | 4-(4-Hydroxyphenyl)butanenitrile | HCID 13781025 | — |
| Product | 4-[4-[5-Methyl-2-(2-naphthyl)-4-oxazolylmethoxy]phenyl]butyronitrile | HCID 11728672 | — |
Reaction Steps
According to the method described for Reference Example 45, 4-chloromethyl-5-methyl-2-(2-naphthyl)oxazole was allowed to react with 4-(4-hydroxyphenyl)butyronitrile to give 4-[4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]phenyl]butyronitrile. Recrystallization from chloroform-ether gave colorless prisms, m.p.149°-151° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05591862 |
| Source dataset | uspto-grants-1997_01 |
| ORD ID | ord-3e8c725afc234ad6bbca1b77f914e23d |
| Source note | uspto-grants-1997_01 |