Trimethyl phosphonoacetate → HCID 53876663, compound

HRID 233323Notes

Reaction equation

HRID 233323 reaction equation
[CH3:1][C:2]1[O:6][C:5]([CH2:7][O:8][C:9]2[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=2[CH:11]=O)=[N:4][C:3]=1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[CH3:23][O:24][C:25]([CH2:27]P(OC)(OC)=O)=[O:26]>>[CH3:1][C:2]1[O:6][C:5]([CH2:7][O:8][C:9]2[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=2[CH:11]=[CH:27][C:25]([O:24][CH3:23])=[O:26])=[N:4][C:3]=1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 80029Trimethyl phosphonoacetateHCID 23361374HCID 23361374, compound

Product 1

HCID 53876663HCID 53876663, compound

Procedure

According to the method described for Reference Example 22, 2-(5-methyl-4-phenyl-2-oxazolylmethoxy)benzaldehyde was allowed to react with trimethyl phosphonoacetate to give methyl 2-(5-methyl-4-phenyl-2-oxazolylmethoxy)cinnamate. Recrystallization from ethyl acetate--chloroform-ether gave colorless prisms, m.p.128°-129° C.

Sources & evidence

ORD record
ord-910ddf799d254054bb01084480da4419
Source dataset
uspto-grants-1997_01
Patent number
US05591862

Reaction notes

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