HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Hydroxyphenyl)butanenitrile → 4-[4-[2-(Benzo[b]furan-2-yl)-5-methyl-4-oxazolylmethoxy]phenyl]butyronitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Hydroxyphenyl)butanenitrile | HCID 13781025 | — |
| Reactant | 2-(Benzo[b]furan-2-yl)-4-chloromethyl-5-methyloxazole | HCID 23361376 | — |
| Product | 4-[4-[2-(Benzo[b]furan-2-yl)-5-methyl-4-oxazolylmethoxy]phenyl]butyronitrile | HCID 10861638 | — |
Reaction Steps
According to the method described for Reference Example 45, 2-(benzo[b]furan-2-yl)-4-chloromethyl-5-methyloxazole was allowed to react with 4-(4-hydroxyphenyl)butyronitrile to give 4-[4-[2-(benzo[b]furan-2-yl)-5-methyl-4-oxazolylmethoxy]phenyl]butyronitrile. Recrystallization from dichloromethane--isopropyl ether gave colorless prisms, m.p.118°-119° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05591862 |
| Source dataset | uspto-grants-1997_01 |
| ORD ID | ord-7fc8fa36c3654050acd49698aaca8b12 |
| Source note | uspto-grants-1997_01 |