HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Hydroxyphenyl)butanenitrile → 4-[4-[2-(Furan-2yl)-5-methyl-4-oxazolylmethoxy]phenyl]butyronitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Hydroxyphenyl)butanenitrile | HCID 13781025 | — |
| Reactant | 4-(Chloromethyl)-2-(furan-2-yl)-5-methyl-1,3-oxazole | HCID 22344582 | — |
| Product | 4-[4-[2-(Furan-2yl)-5-methyl-4-oxazolylmethoxy]phenyl]butyronitrile | HCID 11110069 | — |
Reaction Steps
According to the method described for Reference Example 45, 4-chloromethyl-2-(furan-2-yl)-5-methyloxazole was allowed to react with 4-(4hydroxyphenyl)butyronitrile to give 4-[4-[2-(furan-2yl)-5-methyl-4-oxazolylmethoxy]phenyl]butyronitrile as an oily product. NMR(δ ppm in CDCl3): 1.85-2.05(2H,m), 2.31(2H,t,J=7Hz), 2.42(3H,s), 2.72(2H,t,J=7.5Hz), 4.97(2H,s), 6.52(1H,dd,J=3.5&2Hz), 6.9-7.0(3H,m), 7.10(2H,d,J=9Hz), 7.53(1H,dd,J=2&1Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05591862 |
| Source dataset | uspto-grants-1997_01 |
| ORD ID | ord-3cc472ce382b4921861f0cb4b2561b34 |
| Source note | uspto-grants-1997_01 |