4-(4-Hydroxyphenyl)butanenitrile → 4-[4-(1-Methyl-5-phenyl-1,2,4-triazol-3-ylmethoxy)phenyl]butyronitrile

HRID 233329Notes

Reaction equation

HRID 233329 reaction equation
Cl[CH2:2][C:3]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]([CH3:14])[N:4]=1.[OH:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][CH2:24][C:25]#[N:26])=[CH:18][CH:17]=1>>[CH3:14][N:5]1[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:7][C:3]([CH2:2][O:15][C:16]2[CH:17]=[CH:18][C:19]([CH2:22][CH2:23][CH2:24][C:25]#[N:26])=[CH:20][CH:21]=2)=[N:4]1

Participants

3

Reactant 2

HCID 137810254-(4-Hydroxyphenyl)butanenitrileHCID 233613693-(chloromethyl)-1-methyl-5-phenyl-1H-1,2,4-triazole

Product 1

HCID 110781004-[4-(1-Methyl-5-phenyl-1,2,4-triazol-3-ylmethoxy)phenyl]butyronitrile

Procedure

According to the method described for Reference Example 45, 3-chloromethyl-1-methyl-5-phenyl-1,2,4-triazole was allowed to react with 4-(4-hydroxyphenyl)butyronitrile to give 4-[4-(1-methyl-5-phenyl-1,2,4-triazol-3-ylmethoxy)phenyl]butyronitrile. Recrystallization from dichloromethane-isopropyl ether gave colorless prisms, m.p.106°-107° C.

Sources & evidence

ORD record
ord-9542f557bfd949aaa42b8056b17e9602
Source dataset
uspto-grants-1997_01
Patent number
US05591862

Reaction notes

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