HCID 178434833, compound → HCID 178434835, compound

HRID 233332Notes

Reaction equation

HRID 233332 reaction equation
[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:13][O:14][C:15]1[CH:27]=[CH:26][C:18](/[CH:19]=[CH:20]/[C:21]2[NH:25][N:24]=[N:23][N:22]=2)=[CH:17][CH:16]=1>[C].[Pd].O1CCOCC1>[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:13][O:14][C:15]1[CH:27]=[CH:26][C:18]([CH2:19][CH2:20][C:21]2[NH:22][N:23]=[N:24][N:25]=2)=[CH:17][CH:16]=1

Participants

4

Reactant 1

HCID 178434833HCID 178434833, compound

Product 1

HCID 178434835HCID 178434835, compoundYield 81%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 312751,4-DioxaneSolvent

Procedure

A mixture of (E)-5-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)styryl]tetrazole (1.0 g), palladium-carbon (5%, 0.5 g) and dioxane (100 ml) was subjected to catalytic hydrogenation at room temperature. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure to give 5-[2-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]ethyl]tetrazole (0.81 g, 81%), which was recrystallized from methanol-chloroform to yield colorless plates, m.p.203°-204° C.

Workup

  1. customwas subjected to catalytic hydrogenation at room temperature
  2. filtrationThe catalyst was filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-0fc91b8ae7a042bb8e986bb787b7df24
Source dataset
uspto-grants-1997_01
Patent number
US05591862

Reaction notes

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