Acetic Acid → 2-(4-Aminophenoxy)-2-methylpropanoic acid

HRID 233348Notes

Reaction equation

HRID 233348 reaction equation
[NH:1]([C:5]1[CH:17]=[CH:16][C:8]([O:9][C:10]([CH3:15])([CH3:14])[C:11]([OH:13])=[O:12])=[CH:7][CH:6]=1)C(C)=O.C(O)(=O)C>[OH-].[K+]>[NH2:1][C:5]1[CH:6]=[CH:7][C:8]([O:9][C:10]([CH3:15])([CH3:14])[C:11]([OH:13])=[O:12])=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 148798552-(4-Acetamidophenoxy)-2-methylpropanoic acid

Product 1

HCID 27749582-(4-Aminophenoxy)-2-methylpropanoic acidYield 62%

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent

Procedure

1.18 g (0.005 mol) of the 2-(4-acetaminophenoxy)-2-methyl propionic acid is boiled in 10% KOH (60 ml) for 1/2 hour. The solution is then cooled and acidified with acetic acid to yield 0.6 g (62% yield) of 2-(4-aminophenoxy)-2-methyl propionic acid as a yellowish white powder, mp 214°-216° C.

Workup

  1. temperatureThe solution is then cooled

Sources & evidence

ORD record
ord-3a5b49e3e09c41959c260345e4d29c18
Source dataset
uspto-grants-1997_01
Patent number
US05591892

Reaction notes

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