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HRID233357

反应详情

EQUATION

反应方程式

HRID 233357 的结构方程式

REACTANTS

反应物

3
结构：CO
HCID887

Methanol

CH4O

结构：CC(C)c1nc(COC(=O)N[C@H](C(=O)O)C(C)C)cs1
HCID10542235

未命名化合物

结构：N[C@H](Cc1cncs1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1
HCID15850561

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)c1nc(COC(=O)N[C@H](C(=O)N[C@H](Cc2cncs2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1
HCID482967

N-[4-Hydroxy-5-({hydroxy[(1,3-thiazol-5-yl)methoxy]methylidene}amino)-6-phenyl-1-(1,3-thiazol-5-yl)hexan-2-yl]-2-[(hydroxy{[2-(propan-2-yl)-1,3-thiazol-4-yl]methoxy}methylidene)amino]-3-methylbutanimidic acid

C33H42N6O6S3

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Using the procedure of Example 1U but replacing (2S,3S,5S)-5-amino-2-(N-((5-thiazolyl)methoxycarbonyl)amino)-1,6-diphenyl-3-hydroxyhexane with (2S,3S,5S)-5-amino-1-phenyl-2-(N-((5-thiazolyl)methoxycarbonyl)amino)-6-(5-thiazolyl)-3-hydroxyhexane and replacing N-((N-methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)carbonyl)-L-valine with N-((2-isopropyl-4-thiazolyl)methoxycarbonyl)valine provided, after silica gel chromatography using 10% methanol in dichloromethane, 25 mg (76%) of the desired compound (Rf 0.47, 10% methanol in dichloromethane). Mass spectrum: (M+H)+ =715.

WORKUP

后处理

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