Hydrochloric Acid → CID 14809028

Participants

Reaction Steps

[1R]2-(2',3'-Cyclohexylidenedioxyphenyl)-3-phenylethanol was converted to [1S,3R]1-aminomethyl-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran by the procedures detailed in Step 3 of Example 47 and Steps 1-3 of Example 48, m.p. 158°-160° C.; [alpha]D=110° (c 0.52, 1N HCl); DCI MS: 272 (M+H)+. Analysis calculated for C16H18ClNO3 : C, 60.60; H, 6.05; N, 4.42. Found: C, 60.71; H, 6.2; N, 4.31.

Provenance & Evidence