3-Fluoro-5-(trifluoromethyl)benzylamine → 3-[(2-fluoro-4-iodophenyl)amino]-N-[3-fluoro-5-(trifluoromethyl)benzyl]isonicotinamide
Reaction equation
[F:19][c:20]1[cH:21][c:22]([CH2:23][NH2:24])[cH:25][c:26]([C:28]([F:29])([F:30])[F:31])[cH:27]1.[F:1][c:2]1[c:3]([NH:9][c:10]2[c:11]([C:12](=[O:13])[OH:14])[cH:15][cH:16][n:17][cH:18]2)[cH:4][cH:5][c:6]([I:8])[cH:7]1>>[F:1][c:2]1[c:3]([NH:9][c:10]2[c:11]([C:12](=[O:14])[NH:24][CH2:23][c:22]3[cH:21][c:20]([F:19])[cH:27][c:26]([C:28]([F:29])([F:30])[F:31])[cH:25]3)[cH:15][cH:16][n:17][cH:18]2)[cH:4][cH:5][c:6]([I:8])[cH:7]1Participants
3
Sources & evidence
- ORD record
- ord-40947a6d52c04fa7a45c2a3880e07c2c
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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