HCID 86750154, compound → HCID 86750153, compound

Participants

Reaction Steps

N,N-Dimethyl-2-aminomethylene-4-methylpheno1 (11.5 g, 57.8 mmol as 97.3% pure), was added slowly to n-BuLi (44 ml of a 1.6M solution in hexane, 70.25 mmol) in toluene (30 ml). A very exothermic reaction occurred and the mixture was cooled whilst addition was taking place. A clear straw coloured solution resulted, which was continually stirred until the temperature dropped to ambient. Solvent was next removed until a white precipitate formed. From which recrystallisation from hexane by refrigeration (12 h) caused large pyramidal crystals to form.

Provenance & Evidence