2-Fluorobenzoyl chloride → 2-Fluorobenzoyl-aminoacetonitrile

HRID 233429Notes

Reaction equation

HRID 233429 reaction equation
Cl.[NH2:2][CH2:3][C:4]#[N:5].[F:6][C:7]1[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=1[C:9](Cl)=[O:10].C(=O)([O-])[O-].[Na+].[Na+]>O>[F:6][C:7]1[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=1[C:9]([CH:3]([NH2:2])[C:4]#[N:5])=[O:10]

Participants

5

Reactant 3

HCID 98082-Fluorobenzoyl chlorideHCID 10340Sodium CarbonateHCID 11491918Aminoacetonitrile hydrochloride

Product 1

HCID 197086132-Fluorobenzoyl-aminoacetonitrile

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

14.8 g Aminoacetonitrile hydrochloride was dissolved in 80 ml water. The solution was stirred while 25.37 g 2-fluorobenzoylchloride and a solution of 21.2 g sodium carbonate in 120 ml water were dropped simultaneously from two dropping funnels into it. The mixture was stirred overnight. The precipitate was filtered by suction and recrystallised from methanol plus water, filtered and dried.

Workup

  1. filtrationThe precipitate was filtered by suction
  2. customrecrystallised from methanol plus water
  3. filtrationfiltered
  4. customdried

Sources & evidence

ORD record
ord-2ea521e6a26344889daf4372bf9323c4
Source dataset
uspto-grants-1997_01
Patent number
US05593946

Reaction notes

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