3-(Ethoxycarbonyl)-4-fluorophenylboronic Acid (contains varying amounts of Anhydride) → 3'-Chloro-4'-[2-(4-ethyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-4-fluoro-biphenyl-3-carboxylic acid ethyl ester
Reaction equation
[Cl:1][c:2]1[cH:3][c:4]([O:29][S:30]([C:31]([F:32])([F:33])[F:34])(=[O:35])=[O:36])[cH:5][cH:6][c:7]1[CH:8]([C:9]([C:10]([F:11])([F:12])[F:13])([OH:14])[c:15]1[cH:16][cH:17][c:18]2[c:19]([cH:27]1)[N:20]([CH2:25][CH3:26])[C:21](=[O:24])[CH2:22][O:23]2)[CH3:28].[F:37][c:38]1[c:39]([C:47](=[O:48])[O:49][CH2:50][CH3:51])[cH:40][c:41]([B:44]([OH:45])[OH:46])[cH:42][cH:43]1>>[Cl:1][c:2]1[cH:3][c:4](-[c:41]2[cH:40][c:39]([C:47](=[O:48])[O:49][CH2:50][CH3:51])[c:38]([F:37])[cH:43][cH:42]2)[cH:5][cH:6][c:7]1[CH:8]([C:9]([C:10]([F:11])([F:12])[F:13])([OH:14])[c:15]1[cH:16][cH:17][c:18]2[c:19]([cH:27]1)[N:20]([CH2:25][CH3:26])[C:21](=[O:24])[CH2:22][O:23]2)[CH3:28]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-ac3e891c2b5a4b2b8d4a8093c3ad1653
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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