N-bromobutanimide → HCID 23356418, compound

HRID 233451Notes

Reaction equation

HRID 233451 reaction equation
[CH3:1][C:2]1[C:3]2[N:4]([CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:6][N:7]=1.[Br:11]N1C(=O)CCC1=O>C(Cl)(Cl)Cl>[Br:11][C:8]1[N:4]2[CH:5]=[CH:6][N:7]=[C:2]([CH3:1])[C:3]2=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 5834321-Methylpyrrolo[1,2-a]pyrazine

Product 1

HCID 23356418HCID 23356418, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

5.0 g of 1-methylpyrrolo[1,2-a]pyrazine prepared in Preparation Example 2 was dissolved in 60 ml of chloroform; and 6.7 g of N-bromosuccinimide was added thereto at 0° C. The reaction mixture was stirred for 30 minutes at the same temperature; and the resulting solution was concentrated. The residue was chromatographed over silica gel to obtain 6.3 g of title compound (yield: 80%).

Workup

  1. customat 0° C
  2. concentrationand the resulting solution was concentrated
  3. customThe residue was chromatographed over silica gel

Sources & evidence

ORD record
ord-cba6b8594672446fbc9a9eb364e253d2
Source dataset
uspto-grants-1997_01
Patent number
US05593984

Reaction notes

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