Sodium Cyanide → HCID 23356434, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4.3 g of 6-bromo-1-methylpyrrolo[1,2-a]pyrazine dissolved in 50 ml of N-methylpyrrolidone was added 4.5 g of copper(I) cyanide. The resulting solution was stirred at 150° C. for 5 hours, and then cooled to room temperature. To the reaction mixture was added 100 ml of sodium cyanide solution; and the resulting solution was extracted with ethyl acetate(100 ml×3). The organic layer was concentrated to dryness to obtain 2.5 g of title compound.

Provenance & Evidence