2-Mercaptoethanol → HCID 23356505, compound

HRID 233457Notes

Reaction equation

HRID 233457 reaction equation
Br[C:2]1[N:6]2[CH:7]=[CH:8][N:9]=[CH:10][C:5]2=[CH:4][CH:3]=1.[CH2:11]([OH:14])[CH2:12][SH:13]>C(#N)C>[OH:14][CH2:11][CH2:12][S:13][C:2]1[N:6]2[CH:7]=[CH:8][N:9]=[CH:10][C:5]2=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 15672-MercaptoethanolHCID 23356511HCID 23356511, compound

Product 1

HCID 23356505HCID 23356505, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

2.5 g of 6-bromopyrrolo[1,2-a]pyrazine prepared in Preparation Example 7 was dissolved in 30 ml of acetonitrile; and 1 ml of 2-thioethanol was added thereto. The reaction mixture was refluxed for 12 hours, cooled to room temperature, poured into ice-water and then extracted with ethyl acetate (50 ml×3). The organic layer was concentrated to dryness under a reduced pressure. The residue was chromatographed over silica gel to obtain 1 g of title compound.

Workup

  1. temperatureThe reaction mixture was refluxed for 12 hours
  2. extractionextracted with ethyl acetate (50 ml×3)
  3. concentrationThe organic layer was concentrated to dryness under a reduced pressure
  4. customThe residue was chromatographed over silica gel

Sources & evidence

ORD record
ord-78e04b7c48b647e884205abbbc4489fe
Source dataset
uspto-grants-1997_01
Patent number
US05593984

Reaction notes

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