Chlorosuccinimide → 8-Chloropyrrolo[1,2-a]pyrazine

Participants

Reaction Conditions

Reaction Steps

3.6 g of pyrrolo[1,2-a]pyrazine prepared in Preparation Example 1 was dissolved in a mixture of 20 ml of dimethyl sulfoxide and 20 ml of ethyl acetate; and 4.8 g of N-chloro succinimide was added thereto. The reaction mixture was stirred at 60° C. for 6 hours, poured into ice-water, extracted with ethyl acetate(100 ml×3), and then concentrated under a reduced pressure. The residue was chromatographed over silica gel to obtain 0.6 g of 6-chloropyrrolo[1,2-a]pyrazine and 0.4 g of 8-chloropyrrolo[1,2-a]pyrazine, respectively.

Provenance & Evidence