Pyrrolo[1,2-a]pyrazin-6-ylmethanol → Pyrrolo[1,2-a]pyrazine-6-carbaldehyde

Participants

Reaction Steps

7.28 of 6-hydroxymethylpyrrolo[1,2-a]pyrazine prepared in Preparation Example 18 was dissolved in 400 ml of dioxane; and 10 g of manganese(IV) dioxide was added thereto. The reaction mixture was refluxed for 30 minutes and then cooled to room temperature. The resulting solution was filtered; and the filtrate was concentrated under a reduced pressure to yield 5.3 g of title compound.

Provenance & Evidence