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HRID233497

反应详情

EQUATION

反应方程式

HRID 233497 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)CC(O)(CC(=O)O)C(=O)O
HCID311

Citric acid

C6H8O7

结构：CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)[C@@H](N5CCOC(C)(C)C5)C[C@]4(C)[C@H]3C(=O)C[C@]12C
HCID9803583

(2β,3α,5α)-2-(2,2-Dimethyl-4-morpholinyl)-3-hydroxypregnane-11,20-dione

C27H43NO4

PRODUCTS

生成物

1
结构：CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)[C@@H](N5CCOC(C)(C)C5)C[C@]4(C)[C@H]3C(=O)C[C@]12C.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-]
HCID86750169

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

2 次

PROCEDURE

实验过程

A solution of citric acid (368 mg) in methanol (4 ml) was added to a solution of (2β,3α,5α)-3-hydroxy-2-(2,2-dimethyl-4-morpholinyl)pregnane-11,20-dione of Example 1 (854 mg) in methanol (6 ml). The solvent was removed under reduced pressure to give (2β,3α,5α)-3-hydroxy-2-(2,2-dimethyl-4-morpholinyl)-pregnane-11,20-dione 2-hydroxy-1,2,3-propanetricarboxylate (1:1) salt (1.22 g). [α]D +96.6° (c 1.03).

WORKUP

后处理

  1. customThe solvent was removed under reduced pressure