HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonic Acid → (2beta,3alpha,5alpha)-21-Chloro-3-hydroxy-2-(2,2-dimethyl-4-morpholinyl)-pregnane-11,20-dione methanesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonic Acid | HCID 6395 | — |
| Reactant | (2beta,3alpha,5alpha)-21-Chloro-3-hydroxy-2-(2,2-dimethyl-4-morpholinyl)pregnane-11,20-dione | HCID 10672358 | — |
| Product | (2beta,3alpha,5alpha)-21-Chloro-3-hydroxy-2-(2,2-dimethyl-4-morpholinyl)-pregnane-11,20-dione methanesulfonate | HCID 88359603 | — |
Reaction Steps
With the 21-chloro compound of Example 2 and methanesulfonic acid as starting materials, (2β,3α,5α)-21-chloro-3-hydroxy-2-(2,2-dimethyl-4-morpholinyl)-pregnane-11,20-dione methanesulfonate (1:1) salt was formed. [α]D +104.3° (c 1.20).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05593983 |
| Source dataset | uspto-grants-1997_01 |
| ORD ID | ord-3528cfae836143b0ba58f66639764c33 |
| Source note | uspto-grants-1997_01 |