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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 233500Generated: October 30, 2026

Methanesulfonic Acid → (2beta,3alpha,5alpha)-21-(Acetyloxy)-3-hydroxy-2-(2,2-dimethyl-4-morpholinyl)pregnane-11,20-dione methanesulfonate

https://huagongshe.com/reaction/233500

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanesulfonic AcidHCID 6395—
Reactant(2beta,3alpha,5alpha)-21-(Acetyloxy)-3-hydroxy-2-(2,2-dimethyl-4-morpholinyl)pregnane-11,20-dioneHCID 10529493—
Product(2beta,3alpha,5alpha)-21-(Acetyloxy)-3-hydroxy-2-(2,2-dimethyl-4-morpholinyl)pregnane-11,20-dione methanesulfonateHCID 88359604—

Reaction Steps

With the 21-(acetyloxy) compound of Example 4 and methanesulfonic acid as starting materials, (2β,3α,5α)-21-(acetyloxy)-3-hydroxy-2-(2,2-dimethyl-4-morpholinyl)pregnane-11,20-dione methanesulfonate (1:1) salt was formed. [α]D +99.4° (c 0.81).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05593983
Source datasetuspto-grants-1997_01
ORD IDord-ddfe6adc002343c3ab1602d712f0f949
Source noteuspto-grants-1997_01