Citric Acid → HCID 131719788, compound

HRID 233501Notes

Reaction equation

[OH:1][C@@H:2]1[C@@H:21]([N:22]2[CH2:27][C@H:26]([CH3:28])[O:25][C@H:24]([CH3:29])[CH2:23]2)[CH2:20][C@@:19]2([CH3:30])[C@@H:4]([CH2:5][CH2:6][C@@H:7]3[C@@H:18]2[C:17](=[O:31])[CH2:16][C@@:15]2([CH3:32])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:12](=[O:14])[CH3:13])[CH2:3]1.[C:33]([OH:45])(=[O:44])[CH2:34][C:35]([CH2:40][C:41]([OH:43])=[O:42])([C:37]([OH:39])=[O:38])[OH:36]>>[OH:1][C@@H:2]1[C@@H:21]([N:22]2[CH2:27][C@H:26]([CH3:28])[O:25][C@H:24]([CH3:29])[CH2:23]2)[CH2:20][C@@:19]2([CH3:30])[C@@H:4]([CH2:5][CH2:6][C@@H:7]3[C@@H:18]2[C:17](=[O:31])[CH2:16][C@@:15]2([CH3:32])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:12](=[O:14])[CH3:13])[CH2:3]1.[OH:36][C:35]([C:37]([O-:39])=[O:38])([CH2:40][C:41]([O-:43])=[O:42])[CH2:34][C:33]([O-:45])=[O:44]

Participants

Reactant 2

HCID 311Citric Acid

HCID 10647003HCID 10647003, compound

Product 1

HCID 131719788HCID 131719788, compound

Procedure

With the cis-2,6-dimethyl-4-morpholinyl compound of Example 5 and citric acid as starting materials, (2β,3α,5α)-3-hydroxy-2-(cis-2,6-dimethyl-4-morpholinyl)pregnane-11,20-dione 2-hydroxy-1,2,3-propanetricarboxylate (1:1) salt was formed. [α]D +100.5° (c 1.09).

Sources & evidence

ORD record: ord-86b74d6301244aae84dc71bb1f9fc4c8
Source dataset: uspto-grants-1997_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05593983

Reaction notes

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