Methanesulfonic Acid → (2beta,3alpha,5alpha)-3,21-Dihydroxy-2-(2,2-dimethyl-4-morpholinyl)pregnan-20-one methanesulfonate

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Reaction Steps

A solution of methanesulfonic acid (429 mg) in methanol (10 ml) was added to a solution of the (2β,3α,5α)-3,21-dihydroxy-2-(2,2-dimethyl-4-morpholinyl)pregnan-20-one of Example 9 (2.0 g) in methanol (20 ml). The solvent was removed under reduced pressure to afford (2β,3α,5α)-3,21-dihydroxy-2-(2,2-dimethyl-4-morpholinyl)pregnan-20-one methanesulfonate (1:1) salt (2.43 g). [α]D +108.4° (c 0.6).

Provenance & Evidence