5-(Difluoromethoxy)picolinic acid → (E)-5-(Difluoromethoxy)-N-(8-(hydroxymethyl)-9-methyl-6,7-dihydro-5H-benzo[7]annulen-2-yl)picolinamide
Reaction equation
[F:16][CH:17]([O:18][c:19]1[cH:20][cH:21][c:22]([C:25](=[O:26])[OH:27])[n:23][cH:24]1)[F:28].[NH2:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:15]1)[C:7]([CH3:14])=[C:8]([CH2:12][OH:13])[CH2:9][CH2:10][CH2:11]2>>[NH:1]([c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:15]1)[C:7]([CH3:14])=[C:8]([CH2:12][OH:13])[CH2:9][CH2:10][CH2:11]2)[C:25]([c:22]1[cH:21][cH:20][c:19]([O:18][CH:17]([F:16])[F:28])[cH:24][n:23]1)=[O:26]Participants
3
Sources & evidence
- ORD record
- ord-fae1bc96b321433c8d40b4301e5c31f4
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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