Acetate → 2-(2-Bromopyridine-4-carbonyl)-6-fluorobenzonitrile

HRID 2335226Notes

Reaction equation

HRID 2335226 reaction equation
[Br:1][c:2]1[n:3][cH:4][cH:5][c:6]([C:8]([S:9][CH2:10][CH3:11])=[O:12])[cH:7]1.[C:14](#[N:15])[c:16]1[c:17]([Zn+:23])[cH:18][cH:19][cH:20][c:21]1[F:22].[CH3:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1.[I-:13].[O-:32][C:33]([CH3:34])=[O:35].[O-:36][C:37]([CH3:38])=[O:39].[Pd+2:31]>>[Br:1][c:2]1[n:3][cH:4][cH:5][c:6]([C:8](=[O:12])[c:17]2[c:16]([C:14]#[N:15])[c:21]([F:22])[cH:20][cH:19][cH:18]2)[cH:7]1

Participants

7

Reactant 6

HCID 175Acetate2×HCID 1140TolueneHCID 30165Iodide IonHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 58579502S-ethyl 2-bromopyridine-4-carbothioateHCID 178510274HCID 178510274, compound

Product 1

HCID 585795282-(2-Bromopyridine-4-carbonyl)-6-fluorobenzonitrile

Sources & evidence

ORD record
ord-015312802180423f93dcefcfdc2202f2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

Loading…