2-Methoxypropene → HCID 54558176, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of methyl glycolate (5 ml, 64.8 mmol) and 2-methoxypropene (12.5 ml, 130.5 mmol) in dry dichloromethane (15 ml) at 0° C. was added catalytic amount of pyridinium p-toluene-sulfonate (100 mg). The mixture was stirred at 0° C. for 2 hours. Saturated sodium bicarbonate solution was added and methylene chloride layer was separated, dried over anhydrous magnesium sulfate. Solvent was evaporated and the product was distilled over anhydrous potassium carbonate under reduced pressure (20 mmHg) at 62°-64° C. (yield=9.9 g, 94%), 1H NMR (300 MHz, D6 -acetone) d:1.28 (6H, s), 3.15 (3H, s), 3.67 (3H, s), 4.01 (2H, s).

Provenance & Evidence