HCID 9844021, compound → HCID 178421253, compound

HRID 233645Notes

Reaction equation

HRID 233645 reaction equation
[NH2:1][CH2:2][CH2:3][O:4][C@H:5]1[CH2:22][CH2:21][C@@:20]2([CH3:23])[C@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:19]2[CH2:18][CH2:17][C@@:15]2([CH3:16])[C@:11]3([OH:29])[CH2:12][CH2:13][C@@H:14]2[C:24]2[CH:28]=[CH:27][O:26][CH:25]=2)[CH2:6]1.[N+:30]([O-:33])([O-])=[O:31].CC1([C:41]([NH2:43])=[NH2+:42])C=C(C)N=N1>C(O)C>[N+:30]([O:29][C@@:11]12[C@H:10]3[C@@H:19]([C@:20]4([CH3:23])[C@H:7]([CH2:8][CH2:9]3)[CH2:6][C@@H:5]([O:4][CH2:3][CH2:2][NH:1][C:41]([NH2:43])=[NH:42])[CH2:22][CH2:21]4)[CH2:18][CH2:17][C@:15]1([CH3:16])[C@@H:14]([C:24]1[CH:28]=[CH:27][O:26][CH:25]=1)[CH2:13][CH2:12]2)([O-:33])=[O:31]

Participants

4

Reactant 2

HCID 9844021HCID 9844021, compoundHCID 67283741HCID 67283741, compound

Product 1

HCID 178421253HCID 178421253, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 0.17 g of 3β-(2-aminoethoxy)-17β-(3-furyl)-5β-androstan-14β-ol (I-aa) in 12 ml of absolute ethanol 0.090 g of 3,5-dimethyl-1-pyrazolylformamidinium nitrate were added and the mixture was kept at reflux for 7 hrs; the ethanol was concentrated under reduced pressure and 0.18 g of the title compound (I-al) crystallized as a white solid.

Workup

  1. temperatureat reflux for 7 hrs
  2. concentrationthe ethanol was concentrated under reduced pressure and 0.18 g of the title compound (I-al)
  3. customcrystallized as a white solid

Sources & evidence

ORD record
ord-bf2d6c1473544bbb8fe6d305da83802a
Source dataset
uspto-grants-1997_01
Patent number
US05593982

Reaction notes

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