Tetrahydrofuran → HCID 19606112, compound

Participants

Reaction Steps

To a solution of 2,4-dihydro-2-phenylpyrazolo[4,3-B]pyrrolizine (6.1 mmol) and 18-Crown-6 (6.1 mmol) in tetrahydrofuran at 0° C. was added potassium hexamethyldisilazide, followed by 4-picolyl chloride (14.6 mmol, free-based in toluene) and the reaction allowed to warm to room temperature overnight. Following normal extractive workup and purification, the title compound was isolated as a solid in 4% yield; mp 169°-170° C.; Anal calc'd. for C26H21N5 : C, 77.40; H, 5.25; N, 17.36. Found: C, 77.01; H, 5.12; N, 17.18. Mass spec m/e 404 (M+1).

Provenance & Evidence