HCID 70087144, compound → HCID 70085628, compound

HRID 233675Notes

Reaction equation

HRID 233675 reaction equation
C([N:4]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH:5]([C:7]([O:9][N+:10]([O-:12])=[O:11])=[O:8])[CH3:6])(=O)C>O.O.O.O.O.O.[Co](Cl)Cl.[OH-].[Na+]>[N+:10]([O:9][C:7](=[O:8])[C@H:5]([CH3:6])[NH:4][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)([O-:12])=[O:11]

Participants

4

Reactant 1

HCID 70087144HCID 70087144, compound

Product 1

HCID 70085628HCID 70085628, compoundYield 37%

Reagents, catalysts & solvents 2

HCID 517166Dichlorocobalt hexahydrateCatalystHCID 14798Sodium HydroxideSolvent

Conditions

Temperature
37 °C

Procedure

To N-acetyl-O-nitrophenyl-DL-alanine (324 g, 1.28 mol), aqueous solution (1.8 liters) of 1N sodium hydroxide was added to dissolved, and acylase (9.0 g) and cobalt (II) chloride hexahydrate (100 mg) were sequentially added, and the mixture was stirred for 2 days at 37° C. After filtering the insoluble matter, the filtrate was evaporated in vacuo, and precipitating crystals were filtered and washed with a small amount of water, and the captioned compound (99.6 g, 37%) was obtained.

Workup

  1. dissolutionto dissolved
  2. filtrationAfter filtering the insoluble matter
  3. customthe filtrate was evaporated in vacuo
  4. customprecipitating crystals
  5. filtrationwere filtered
  6. washwashed with a small amount of water

Sources & evidence

ORD record
ord-3273c947cf91462b80300bf04cd96e00
Source dataset
uspto-grants-1997_01
Patent number
US05594006

Reaction notes

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