HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chlorophenethylamine → N-[2-(3-chlorophenyl)ethyl]-N'-[2-benzothiazolyl]thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chlorophenethylamine | HCID 139381 | — |
| Reactant | N-(benzo[d]thiazol-2-yl)-1H-imidazole-1-carbothioamide | HCID 19703709 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-[2-(3-chlorophenyl)ethyl]-N'-[2-benzothiazolyl]thiourea | HCID 19703698 | 63.2% |
Reaction Steps
A solution of 1-[(2-benzothiazolyl)thiocarbamoyl]imidazole (1.04 g, 4 mmol) and 2-(3-chlorophenyl)ethylamine (0.63 g, 4 retool) in N,N-dimethylformamide (15 mL) was stirred at 100° C. for 1 h, the reaction was cooled to room temperature and the solvent removed in vacuo. The residue was crystallized from ethyl acetate to provide 0.88 g (63%) of the title product:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05593993 |
| Source dataset | uspto-grants-1997_01 |
| ORD ID | ord-d0d028c30722424cb2c5c8ec94049be4 |
| Source note | uspto-grants-1997_01 |