8-Amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one → 8-{5-Chloro-4-[2-fluoro-6-(tetrahydro-furan-3-yloxy)-phenylamino]-pyrimidin-2-ylamino}-1,3,4,5-tetrahydro-1-benzazepin-2-one

HRID 2336859Notes

Reaction equation

HRID 2336859 reaction equation
[Cl:14][c:15]1[n:16][cH:17][c:18]([Cl:35])[c:19]([NH:21][c:22]2[c:23]([F:34])[cH:24][cH:25][cH:26][c:27]2[O:28][CH:29]2[CH2:30][O:31][CH2:32][CH2:33]2)[n:20]1.[NH2:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:13]1)[NH:7][C:8](=[O:12])[CH2:9][CH2:10][CH2:11]2>>[NH:1]([c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:13]1)[NH:7][C:8](=[O:12])[CH2:9][CH2:10][CH2:11]2)[c:15]1[n:16][cH:17][c:18]([Cl:35])[c:19]([NH:21][c:22]2[c:23]([F:34])[cH:24][cH:25][cH:26][c:27]2[O:28][CH:29]2[CH2:30][O:31][CH2:32][CH2:33]2)[n:20]1

Participants

3

Reactant 2

HCID 46151688-Amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-oneHCID 86633996(2,5-Dichloro-pyrimidin-4-yl)-[2-fluoro-6-(tetrahydro-furan-3-yloxy)-phenyl]-amine

Product 1

HCID 668305738-{5-Chloro-4-[2-fluoro-6-(tetrahydro-furan-3-yloxy)-phenylamino]-pyrimidin-2-ylamino}-1,3,4,5-tetrahydro-1-benzazepin-2-one

Sources & evidence

ORD record
ord-7d5f18b60be449648ce6635d74a90d78
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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